Researcher · Bioinformatician · Astrobiologist

Davide Corso

Davide Corso

Bridging microbial ecology, metagenomics and space science — from deep-sea hydrothermal vents to Martian analogues.

→ Research Fellow, CNR-IRSA — Roma Montelibretti

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// 00 — About

Who I Am

I am a computational biologist driven by a single question: how does life adapt to the most extreme conditions on Earth — and what does that tell us about the possibility of life elsewhere? I build bioinformatic tools and pipelines to decode microbial communities, then apply them to environments that push biology to its limits — from deep-sea hydrothermal vents to hypersaline planetary analogues.

Currently a Research Fellow at CNR, my work combines field campaigns — including a dive at 2,518 metres aboard the HOV Alvin — with high-performance computational analysis. I am also increasingly interested in the theoretical principles that govern how microbial communities sustain cooperation and stability under extreme energetic constraints.

// 01 — Research

Research Areas

🧬

Environmental Metagenomics

Characterising microbial communities in extreme and aquatic environments — from constructed wetlands and coastal aquifers to deep-sea hydrothermal vents — using 16S rRNA sequencing and whole-metagenome approaches.

🪐

Astrobiology & Planetary Analogues

Investigating hypersaline and geochemically extreme environments as analogues for Mars and other planetary bodies, with a focus on biosignature formation and the potential for life in extreme conditions.

⚙️

Bioinformatics Tool Development

Designing and maintaining flexible, reproducible pipelines and R packages for metagenomic analysis, spatial transcriptomics, and biological network visualisation — built for scientists without deep computational backgrounds.

🛰️

Earth Observation & Space Data

Applying satellite remote sensing, geospatial analysis and climate system monitoring to environmental research, integrating orbital data with ground-truth biological and geochemical observations.

// 02 — Scientific Output

Scientific Output

Publications

Published
[1]
MyoData: An expression knowledgebase at single cell/nucleus level for the discovery of coding-noncoding RNA functional interactions in skeletal muscle
Corso D., Chemello F., Alessio E., Urso I., Ferrarese G., et al. (2021)
Computational and Structural Biotechnology Journal, 19, 4142–4155 · DOI →
[2]
A thorough annotation of the krill transcriptome offers new insights for the study of physiological processes
Urso I., Biscontin A., Corso D., Bertolucci C., Romualdi C., et al. (2022)
Scientific Reports, 12, 11415 · DOI →
[3]
Surface Bacterioplankton Community Structure Crossing the Antarctic Circumpolar Current Fronts
Cordone A., Selci M., Barosa B., Bastianoni A., …, Corso D., et al. (2023)
Microorganisms, 11(3):702 · DOI →
[4]
Diversity of Thermophilic Prokaryotes
Vilhelmsson O., Sigurbjornsdottir M.A., Thorsteinsdottir G.V., Cascone M., Corso D., et al. (2023)
Thermophilic Anaerobes, Springer · DOI →
[5]
Constructed wetlands for aquaculture wastewater treatment: Insights on the structural and functional shifts of the aquatic microbial community
Corso D., Melita M., Massaccesi N., Quero G.M., Basili M., Di Cesare A., et al. (2026)
Bioresource Technology, 448, 134278 · DOI →
[6]
Ancient Roman saltworks drive the present-day microbial community profiles in the coastal aquifer of the Tiber River delta
Boccanera M., Amalfitano S., Melita M., Corso D., Valle A., Ghergo S., Preziosi E. (2026)
Journal of Hydrology: Regional Studies, 65, 103448 · DOI →
[7]
Freshwater beach sandy sediments harbour latent β-lactamases with deep phylogenetic roots in Chitinophagaceae
Corso D., Iburg S., Coci M., Cordone A., Cesare A.D., Giovannelli D., Sbaffi T., Martínez A., Eckert E.M. (2026)
Preprint · DOI → · Peer Review
[8]
Hydrogenotrophic metabolisms in the subsurface and their implications for underground hydrogen storage and natural hydrogen prospecting
Cascone M., Gargallo G.C., Migliaccio F., Corso D., et al. (2026)
Earth-Science Reviews, 281, 105620 · DOI →
[9]
Geomosaic: A Flexible Bioinformatics Platform Integrating Complementary Metagenomic Analyses from Sequencing Reads to Genomes
Corso D., Taccaliti E., Barosa B., Giovannelli D. (2026)
Preprint, Bioinformatics · DOI → · Peer Review
Forthcoming
[10]
Linking evaporitic crust texture to microbial community structure in a hypersaline environment
Cassarìo A., Corso D.*, Franchi F., Amalfitano S., Kahsay T.H., Pacelli C. Peer Review
*Corresponding author
[11]
itGraph: novel visualization layout of regulatory networks highlights biological modules in pathways
Corso D., Romualdi C., Sales G. Internal Review
[12]
Ironborn: Fe distribution in geothermal fluids and its influence on the biosphere
Barosa B., Corso D., et al. In Preparation
[13]
Polygons plot: a new aesthetics for visualizing multivariate data
Giovannelli D., Corso D., et al. Internal Review

Tools & Packages

Geomosaic

A flexible metagenomic pipeline combining read-based analysis, assemblies and MAGs with downstream biological and geochemical data integration. Designed for reproducibility and ease of use without deep bioinformatic expertise.

Python Snakemake Metagenomics HPC
polygonPlot
GitHub →

An R package for multivariate data range visualisation, displaying 3–6 variables simultaneously with min/max and mean for each — ideal for comparing environmental profiles across sampling sites.

R CRAN Visualisation Multivariate
spatialDE
Bioconductor →

An R/Bioconductor wrapper for the SpatialDE Python library, enabling identification of spatially variable genes in spatial transcriptomics data directly from R with a native Bioconductor interface.

R Bioconductor Spatial Transcriptomics
itGraph
Web App →

A web application for interactive visualisation of biological regulatory networks, combining multiple layout algorithms and network types to highlight functional modules within biological pathways.

React.js Python Cytoscape.js Networks
MyoData
Web App →

An expression knowledgebase at single cell and nucleus level for the discovery of coding–noncoding RNA functional interactions in skeletal muscle, integrating miRNA, lncRNA and mRNA co-regulation networks.

React.js Python SQLite RocksDB Networks
// 03 — Field

Field Experience

February 2024
🤿 Alvin Deep Dive #5229
📍 East Pacific Rise, 9°50'N — Pacific Ocean, 2,518 m depth
Participated as starboard observer aboard the deep-submergence vehicle HOV Alvin for an 8-hour dive to sample hydrothermal vent fluids and biofilms at the Tica and Biovent sites.
January – February 2024
🚢 AT50-20 Oceanographic Expedition — R/V Atlantis
📍 East Pacific Rise, 9°50'N — 104°17'W
31-day NSF-funded oceanographic cruise aboard the WHOI research vessel Atlantis. Sampled high- and low-temperature hydrothermal vent fluids at 2,500 m depth using titanium syringe samplers at sites Tica, Biovent, Bio9, L-Vent and V-Vent.
April 2024
🪨 ICDP-DIVE — Ivrea-Verbano Zone
📍 Ivrea-Verbano, Northern Italy
Participated in the International Continental Drilling Program campaign, responsible for collection, processing and preservation of rock core samples from the lower continental crust exposed at the Ivrea-Verbano Zone.
2025 – Ongoing
💧 VFN Valle del Sacco — Groundwater Sampling
📍 Sacco River Basin, Lazio, Italy
Multiple sampling campaigns across 2025 to characterise the natural geochemical background of groundwater and soil in the Sacco River national interest site (SIN), in collaboration with CNR-IRSA and ARPA Lazio.
// 04 — Experience

Experience

2024 — Present
Postdoctoral Research Fellow
📍 CNR-IRSA — Roma Montelibretti
Research on microbial communities in extreme and aquatic environments, with a focus on metagenomics, antibiotic resistance genomics, and astrobiology. Development and maintenance of open-source bioinformatic tools and pipelines.
PI: Dr. Stefano Amalfitano
2022 — 2024
Postdoctoral Research Fellow
📍 Università degli Studi di Napoli Federico II
Development of new bioinformatic tools for the analysis of microbial diversity in extreme environments using metagenomic approaches. Participation in international field expeditions including the NSF-funded AT50-20 oceanographic cruise aboard R/V Atlantis.
PI: Prof. Donato Giovannelli
2018 — 2019
Research Fellow
📍 Università degli Studi di Padova
Development of computational methods for the reconstruction and analysis of gene interaction networks between protein-coding genes, microRNAs and lncRNAs in relation to metabolic changes in skeletal muscle fibre types.
PI: Dr. Gabriele Sales
// 05 — Education

Education

2026
International Master's programme in Space Missions Science, Design and Applications (SPICES)
Alma Mater Studiorum — Università di Bologna
Microbial community structure and biosignature potential in a hypersaline planetary field analogue: insights from the Kudiakam Pan, Makgadikgadi Basin (Botswana)
2023
PhD in Biosciences — Genetics, Genomics & Bioinformatics
Università degli Studi di Padova
Exploring biological signals: from pathway visualization to spatial transcriptomics
2018
MSc in Bioinformatics
Università degli Studi di Roma Tor Vergata
Analysis of gene expression variation based on associations between DNA:DNA:ncRNA triple helices and epigenetic signals
2017
BSc in Computer Science
Università degli Studi di Roma Tor Vergata
Analysis of secondary structure prediction stability as a function of flanking sequences in non-coding RNAs
// 06 — Academia

Academia

Teaching

AY 2023/2024
Microbial Colonization of Terrestrial Analogs and Habitability
📍 MSc in Biology of Extreme Environments — Università degli Studi di Napoli Federico II
Teaching assistant. Course held by Prof. Donato Giovannelli. Topics covered microbial colonization strategies in extreme terrestrial environments and their implications for planetary habitability research.
AY 2019/2020 · 2020/2021 · 2021/2022
Molecular Genetics
📍 MSc in Molecular Biology — Università degli Studi di Padova
Teaching assistant for three consecutive academic years. Course held by Prof. Gabriele Sales. Supported students in understanding molecular genetics principles and their computational applications.
AY 2020/2021 · 2021/2022
Omic Data: Analysis and Experimental Design
📍 BSc in Molecular Biology — Università degli Studi di Padova
Teaching assistant for two academic years. Course held by Prof. Chiara Romualdi and Prof. Gabriele Sales. Covered experimental design and computational analysis of multi-omic datasets including RNA-seq and related technologies.

Conferences & Talks

🏆 Poster Award
Flow cytometry as a tool to track microbial community shifts in constructed wetlands treating Aquaculture Effluents
43^ Conferenza Nazionale di Citometria (Cytometry 2025) — Category: Environment
Invited Talk
Geomosaic: A flexible metagenomic pipeline combining biological and geochemical data
CNR-IRSA Verbania — July 2024
Poster
Geomosaic: A flexible metagenomic pipeline combining biological and geochemical data
SIMGBM — Cagliari, September 2024
Flash Talk
Geomosaic: A flexible metagenomic pipeline combining biological and geochemical data
SIA — Società Italiana di Astrobiologia, Roma — June 2024
Poster
Novel visualization layout of regulatory networks highlights biological modules in pathway
5° Retreat Scientifico, Dipartimento di Biologia, Padova — May 2022

Workshops & Training

🪐 ESA
Introduction to Planetary Protection
European Space Agency — Fraunhofer IPA, Stuttgart, Germany · September–October 2025
🔭 INAF
Rosetta e la Cometa
Istituto Nazionale di Astrofisica — Osservatorio Astronomico di Capodimonte, Napoli · June 2024
🖥️ ICME 13
Crash course on Nanopore sequencing for microbial ecology
ICME 13 — CNR-IRSA, Roma — March 2024
🧬 ICME
Crash Course on Nanopore Sequencing for Microbial Ecology (as Participant)
ICME 12 — CNR-IRSA, Verbania · September 2023
⛰️ ICDP
DIVE Science Workshop — Drilling into the Ivrea-Verbano Zone
ICDP — Romagnano Sesia, Novara · July 2024
💻 HPC
High Performance Bioinformatics
CINECA, Roma · December 2017
// 07 — Affiliations

Affiliations & Initiatives

🧫 MIRA
Co-founder & Bioinformatics Lead — MIRA Biotech
Deep-tech spin-off (CNR / Università della Tuscia) — Microbiome Intelligence platform turning complex microbial data into predictive insight for environmental, industrial, agricultural and space applications · Website →
🔬 MicrobEco
Member — MicrobEco
Scientific association of microbial ecologists — outreach, training (e.g. ICME Series) and international collaboration · Website →
// 08 — Skills

Technical Skills

🧬
Bioinformatics & Genomics
Metagenomics 16S rRNA Analysis MAG Assembly Spatial Transcriptomics RNA-seq Snakemake Machine Learning Network Analysis Nanopore Sequencing
💻
Programming Languages
Python R Bash / Unix JavaScript SQL / PostgreSQL Java HTML / CSS C Matlab Ruby
⚙️
Infrastructure & DevOps
Docker Singularity Slurm / HPC Git / GitHub / GitLab GitHub Actions Conda / Mamba Linux Admin
📊
Data & Visualisation
Bioconductor R packages (CRAN) Cytoscape.js D3.js
🌐
Development
React.js LaTeX SQLite PostgreSQL RocksDB NPM REST APIs CSS / SCSS D3.js
🛰️
Space & Earth Sciences
Earth Observation Geospatial Analysis Satellite Data Processing Astrobiology Planetary Analogues Geochemical Analysis Space Mission Design Image Processing
// 09 — Contact

Get in Touch

I am open to research collaborations, consulting opportunities in bioinformatics and space science, and invitations to speak or teach. If you are working on something at the intersection of computational biology, microbial ecology, or astrobiology — I would love to hear from you.

Send an Email
One more thing, 2,518 m down ↓
// 10 — 2,518 M

Alvin Dive on the East Pacific Rise

HOV Alvin Dive #5229 · East Pacific Rise · 2,518 m